3 Hallmark Signs Of Parkinson's Disease And How Prevent

Worldwide, Parkinson's disease is the neurological disease with the fastest-growing incidence rate, and the incidence of Parkinson's disease in China has increased exponentially. As a common neurodegenerative disease, the diagnosis and treatment of Parkinson's disease requires early detection and early treatment. However, due to the insidious onset and atypical initial symptoms, it is necessary to practice a pair of sharp eyes to identify Parkinson's disease early. It is suggested that everyone, especially high-risk groups, may wish to recall whether they have the following conditions:

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Do you feel like your movements are slowing down?

Heaviness of limbs, fatigue, lack of strength... Some patients in the clinic mistakenly think that they have Parkinson's disease when these conditions occur, but in fact, slow movement is the core symptom of Parkinson's disease. Unlike weakness in limbs, slowness of movement refers to slower and smaller movements, but the strength itself is not affected.

When it comes to Parkinson's disease, many people still think of involuntary shaking. In fact, shaking is not a typical symptom of the disease, and some patients even do not show shaking from beginning to end. A considerable number of "hand shake" patients may be caused by other diseases such as essential tremor.

Is there a problem with the sense of smell and sleep?

 Among the non-motor symptoms, Parkinson's disease can show a decreased sense of smell, behavioral disturbance during rapid eye movement sleep, depressed mood, and constipation. According to statistics, 60% of patients with Parkinson's disease have experienced more than one non-motor symptom, and 25% have more than four, which often appear before motor symptoms. Studies have shown that patients may face hyposmia and constipation 20 years before motor symptoms appear, and sleep disturbances may appear 10 years before. Accordingly, the "International Association for Movement Disorders" published the diagnostic criteria for Parkinson's disease prodrome, indicating that the possibility of future Parkinson's disease can be predicted based on non-motor symptoms, age, gender, etc.

Is there a family history of Parkinson's disease?

 The vast majority of Parkinson's disease are sporadic cases, and only about 10% are hereditary. Nevertheless, first-degree relatives of sporadic cases will still increase the risk of Parkinson's disease by 2 to 3 times. Therefore, people with a family history of Parkinson's disease need to be alert to the above symptoms.

At present, 23 pathogenic loci and 19 pathogenic genes have been identified for Parkinson's disease, and the clinical symptoms caused by different gene defects are also different. Visual hallucinations and ocular myoclonus; patients with PLA2G6 gene mutations often have non-motor symptoms or cognitive decline as the first symptom.